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Scientific Research and Important Links

Scientific Reference Articles about Coronavirus (COVID-19/SARSCoV2)

Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Stubbs B, et al. Cell Press Online July 2020.

From the authors: “Here, we provide an overview of ketone body biology relevant to respiratory viral infection, focusing on
influenza A and severe acute respiratory syndrome (SARS)-CoV-2,and discuss the opportunities, risks, and research gaps in the study of exogenous ketone bodies as novel immunometabolic interventions in these diseases.”

Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19). Taylor Heald-Sargent, MD, PhD, et al. Jama Pediatrics, July 31, 2020

They found children < 5 years carried 10 to 100 x as much virus (SARS CoV 2 or COVID-19) in their respiratory tract compared to children ages 5 to 17 and adults, who had similar levels of virus., suggesting young children can be potent spreaders of this infection.

Scientific Reference Articles about Ketones

NEWEST:

Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease.   Chatterjee P, Fernando M, Fernando B, et al.  Mechanisms of Aging and Development, 2020; 186:e1-10. Full Article Supplemental Materials From Dr. Ralph Martins Alzheimer’s research group in Australia

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Low-Fat Versus Ketogenic Diet in Parkinson’s Disease: A Pilot Randomized Controlled Trial Phillips, MCL, et al. Movement Disorders, Vol. 33, No. 8, 2018.

Dr. Matthew Phillips, a neurologist in New Zealand, and associates report 42% improvement in nonmotor symptoms of Parkinson’s disease with a reasonable healthy-food ketogenic diet compared to healthy-food low-fat diet. Both diets improved motor symptoms as well.  Printable Journal Article  Printable  Ketogenic Diet Used in the Study with Recipes

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Ketone Ester Drink Improves Brain Network Stability After an Overnight Fast Compared to a Calorically Equivalent Glucose Drink. Mujica-Parodi, et al. in PNAS March 2020

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Leading Scientists Agree: Current Limits on Saturated Fats No Longer Justified (Feb 25, 2020)

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Safety and Tolerability of sustained exogenous ketosis using ketone monoester drinks for 28 days in healthy people. Soto-Mota, Clarke, et al. Regulatory Toxicology and Pharmacology (October 2019)

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Lifelong Choline Supplementation Ameliorates Alzheimer’s Disease Pathology and Associated Cognitive Defects by Attenuating Microglia Activation, Velazquez, et al. Aging Cell, Online Library, 2019: 1-11

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A Ketogenic Drink Improves Brain Energy and Some Measures of Cognition in Mild Cognitive Impairment, Fortier, et al. 2019  Alzheimer’s & Dementia, 2019, online:1-10

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Ketogenic Medium Chain Triglycerides Increase Brain Energy Metabolism in Alzheimer’s Disease, Croteau, et al. 2018 

Journal of Alzheimer’s Disease, 2018, 64(2):551-561

MCT oil can fill in the “brain energy gap” that occurs with aging–the difference between how much energy the brain needs and how much it receives.

Lauric Acid Stimulates Ketone Body Production in the KT-5 Astrocyte Cell Line 

Research by University of Tokyo and Nisshin Oillio shows that lauric acid which is 50% of coconut oil stimulates ketone production in astrocytes, which are cells that nourish other brain cells.

A New Way to Produce Hyperketonemia: Use of Ketone Ester in a Case of Alzheimer’s Disease. Newport MT, VanItallie TB, Kashiwaya Y, King MT, Veech RL  Alzheimers Dement. 2015 Jan;11(1):99-103.

Can Ketones Rescue aging brain?, Cunnane, July 2016 Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

Cunnane & Crawford J Human Evol 2014

The energetic constraint was solved in large measure by the evolution in hominins of a unique and significant layer of body fat on the fetus starting during the third trimester of gestation. By providing fatty acids for ketone production that are needed as brain fuel…

Courchesne-Loyer et al PET KD JCBFM 2016

Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study…

A Ketone Ester Diet Exhibits Anxiolytic and Cognition-Sparing Properties and Lessens Amyloid and Tau Pathologies in a Mouse Model of Alzheimer’s Disease. Richard L. Veech, Y Kashiwaya, Neurobiology of Aging, 2012, 1-10

Ketoacids? Good Medicine? George F. Cahill, Jr., Richard L. Veech , Transactions of the American Clinical and Climatological Association , Vol. 114, 2003.

The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, and mitochondrial metabolism Richard L. Veech, Prostaglandins, Leukotrienes and Essential Fatty Acids , 70 (2004) 309-319.

Ketones: Metabolism’s Ugly Duckling, TB VanItallie, TH Nufert, Nutrition Reviews , Oct 2003, Vol. 61, No 10, 327-341.

Hypothesis Paper: Ketone Bodies, Potential Therapeutic Uses. RL Veech, B Chance,Y Kashiwaya, HA Lardy, GF Cahill, Jr., IUBMB Life 2001, Vol. 51, 241247

D-b-Hydroxybutyrate protects neurons in models of Alzheimerâs and Parkinsonâs disease.  Y Kashiwaya, T Takeshima, N Mori, K Nakashima, K Clarke , and RL Veech PNAS May 9, 2000, Vol. 97 No. 10, p. 5440-5444

Alternate Fuel Utilization by Brain. GF Cahill, TT Aoki Cerebral Metabolism and Neural Function 1980, Ch.26

Brain Metabolism during Starvation, OE Owen, AP Morgan, HG Kemp, JM Sullivan, MG Herrera, GF Cahill, Jr., J Clin Invest , 1967, Vol. 46, p. 1589-1595

… ketone bodies, and mitochondrial energy transduction. K Sato, Y Kashiwaya, et. al., including Dr. Richard Veech, Research Communications, The FASEB Journal , Vol. 9, May 1995, p. 651-658

Brain metabolism during fasting. OE Owen, AP Morgan, HG Kemp, JM Sullivan, MG Herrera, GF Cahill Jr ., J Clin Invest, 1967, Vol. 46, p. 1589-95

Cerebral metabolic adaptation and ketone metabolism after brain injury  ML Prins, 2008, Journal of Cerebral Blood Flow and Metabolism , Vol. 28, p. 1-16

D, L-3-hydroxybutyrate treatment of multiple acyl-CoA dehydrogenase deficiency (MADD). J.L.K. Van Hove, et. al., The Lancet Vol. 361, 4/26/2003 p.1433-1435

Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study T. VanItallie, C. Nonas, A Di Rocco, K Boyar, K Hyams and SB Heymsfield, Neurology, 2005, Vol. 64, p. 728-730

Brain Fuel Metabolism, Aging, and Alzheimerâs Disease, S. Cunnane, S Nugent, M Roy, et. al, Nutrition, Jan. 2011

Ketone Bodies as a Fuel for the Brain during Starvation OE Owen, Biochemistry And Molecular Biology Education, 2005, Vol. 33 No. 4, p. 246-251

Medium Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support in vitro Synaptic Transmission During Acute Hypoglycemia.  Kathleen A. Page, et. al., Diabetes, published online 2/17/2009

Scientific articles about a viral connection to Alzheimer’s disease and coconut oil medium chain triglycerides as potential viricidal agents:

Herpes Simplex Virus Type 1 in Alzheimer’s Disease: The Enemy Within RF Itzhaki and MA Wozniak, 2008, Journal of Alzheimer’s Disease , Vol. 13, p. 393-405

Inactivation of Enveloped Viruses and Killing of Cells by Fatty Acids and Monoglycerides H Thormar, CE Isaacs, HR Brown, MR Barshatsky, and T Pessolano, Antimicrobial Agents and Chemotherapy , Jan 1987, Vol. 31 No. 1, p. 27-31

Development and Evaluation of Microbicidal Hydrogels Containing Monoglyceride as the Active Ingredient T Kristmunsdottir, SG Arnadottir, G Bergsson, and H Thormar, Journal of Pharmaceutical Sciences , Oct 1999, Vol. 88 No. 10, p. 1011-1015

Look up online:

www.freepatentsonline.com — Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of Alzheimer’s disease and other diseases resulting from reduced neuronal metabolism,United States Patent 20080009467, Inventor Samuel T. Henderson, Accera, Inc., Broomfield, Colorado (Ketasyn).

www.accerapharma.com — Ketone Bodies as a Therapeutic for Alzheimer’s Disease, ST Henderson, Journal of the American Society for Experimental NeuroTherapeutics, Vol 5, 470-480, July 2008.

Nutrient analysis of coconut oil (vegetable), NDB No: 04047  www.nal.usda.gov/fnic/foodcomp

NEW WEBSITE for people with Mild Cognitive Impairment

You can do something for MCI - learn about proper evaluation and lifestyle changes that could change this common brain aging condition. From Leslie Norins, MD, PhD and his wife Ann Rainey Norins

Real Ketones (D-BHB) – Real Good Price

Real Ketones/Real Good Price

"Kegenix" is now "Real Ketones". All products now the bioavailable D-form of BHB.

Videos: Tripping Over the Truth Conference – Cancer and Alzheimer’s

Please DONATE to the Yu Foundation which funds education & research in ketogenic and other nutritional support for cancer, Alzheimer's and other conditions.

10-Day Ketone Challenge – 20 Serving Variety Pack Box plus 10 days Mitoplex Electrolytes

Want to learn more about ketones? Click Here. Also, download Pruvit TV app.

What is MCT//143?

Mary Newport MD talks about MCT//143 and how it can help you fight brain aging.

For People with Dementia & Care Partners

Dementia Action Alliance (daanow.org) invites people living with any form of dementia and/or care partners to join our Dementia Discussions every Thursday at 1:00 ET, 12:00 CT, 11:00 MT, 10:00 PT. Free video chat - all you need is a phone, tablet, or computer with a camera. Please share! Link: https://zoom.us/j/4567882023

EXPLORE PRUVIT KETONE SALTS & MCT//143

KetoneAid KE4 Ketone Ester — KE1 Ester/Salt Mix

KE4 - D-BHB/Butanediol Ketone Ester from Ketoneaid

Study of Virgin Coconut Oil for COVID-19

Virgin coconut oil contains 60% lauric and capric fatty acids, kills viruses and are used in sprays, wipes, oral and skin care products. Here is a protocol with rationale and how-to-use guidelines to supplement treatment for people with COVID-19 infection and for prevention. Developed by MDs, PhDs at Ateneo University in the Philippines (with my input) and in study at hospitals there. Direct lab testing of the virus is also underway.

Fabric Face Mask with Filter Pocket & Face Shield

This fabric face mask can be sewn in about 30 minutes. There is a pocket for filter insert and demo on making a full face shield. Free patterns available on this website at https://coconutketones.com/coronavirus-info-masks-coconut-oil-study/

Disposable Face Mask with Plastic Barrier

Protect yourself: Make in less than five minutes with everyday items. Click graphic for video.

Cracking Coronavirus by Mary T Newport MD

AOCS 2019 MOST WATCHED WEBINAR!!

ketones

Alzheimer’s disease affects more than 5.8 million Americans and 35 million worldwide

TEDXUSF: Dr. Newport Talks About Coconut Oil and Ketones for Alzheimer’s

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